| 20/09/2020 | Southampton vs Tottenham | 2 - 5 | 68 | 0 |
| 26/09/2020 | Burnley vs Southampton | 0 - 1 | 94 | 2 |
| 04/10/2020 | Southampton vs West Brom | 2 - 0 | 94 | 4 |
| 25/10/2020 | Southampton vs Everton | 2 - 0 | 86 | 2 |
| 01/11/2020 | Aston Villa vs Southampton | 3 - 4 | 97 | 2 |
| 06/11/2020 | Southampton vs Newcastle | 2 - 0 | 94 | 6 |
| 23/11/2020 | Wolverhampton Wanderers vs Southampton | 1 - 1 | 90 | 0 |
| 29/11/2020 | Southampton vs Man United | 2 - 3 | 90 | 0 |
| 07/12/2020 | Brighton vs Southampton | 1 - 2 | 95 | 0 |
| 13/12/2020 | Southampton vs Sheffield United | 3 - 0 | 94 | 6 |
| 16/12/2020 | Arsenal vs Southampton | 1 - 1 | 63 | 0 |
| 26/12/2020 | Fulham vs Southampton | 0 - 0 | 93 | 2 |
| 29/12/2020 | Southampton vs West Ham | 0 - 0 | 16 | 2 |
| 04/01/2021 | Southampton vs Liverpool | 1 - 0 | 94 | 2 |
| 16/01/2021 | Leicester vs Southampton | 2 - 0 | 96 | 0 |
| 26/01/2021 | Southampton vs Arsenal | 1 - 3 | 96 | 4 |
| 30/01/2021 | Southampton vs Aston Villa | 0 - 1 | 98 | 0 |
| 02/02/2021 | Man United vs Southampton | 9 - 0 | 94 | -1 |
| 14/02/2021 | Southampton vs Wolverhampton Wanderers | 1 - 2 | 69 | 2 |
| 23/02/2021 | Leeds United vs Southampton | 3 - 0 | 94 | 0 |
| 01/03/2021 | Everton vs Southampton | 1 - 0 | 96 | -1 |
| 06/03/2021 | Sheffield United vs Southampton | - | - | - |
| 10/03/2021 | Man City vs Southampton | - | - | - |
| 14/03/2021 | Southampton vs Brighton | - | - | - |
| 20/03/2021 | Tottenham vs Southampton | - | - | - |
| 03/04/2021 | Southampton vs Burnley | - | - | - |
| 10/04/2021 | West Brom vs Southampton | - | - | - |
| 17/04/2021 | Southampton vs Crystal Palace | - | - | - |
| 01/05/2021 | Southampton vs Leicester | - | - | - |
| 08/05/2021 | Liverpool vs Southampton | - | - | - |
| 12/05/2021 | Southampton vs Fulham | - | - | - |
| 15/05/2021 | Southampton vs Leeds United | - | - | - |
| 23/05/2021 | West Ham vs Southampton | - | - | - |
