| 12/09/2020 | Crystal Palace vs Southampton | 1 - 0 | 97 | 0 |
| 20/09/2020 | Southampton vs Tottenham | 2 - 5 | 95 | 8 |
| 26/09/2020 | Burnley vs Southampton | 0 - 1 | 94 | 4 |
| 04/10/2020 | Southampton vs West Brom | 2 - 0 | 94 | 0 |
| 17/10/2020 | Chelsea vs Southampton | 3 - 3 | 95 | 4 |
| 25/10/2020 | Southampton vs Everton | 2 - 0 | 96 | 4 |
| 01/11/2020 | Aston Villa vs Southampton | 3 - 4 | 85 | 4 |
| 07/12/2020 | Brighton vs Southampton | 1 - 2 | 50 | 4 |
| 13/12/2020 | Southampton vs Sheffield United | 3 - 0 | 94 | 2 |
| 16/12/2020 | Arsenal vs Southampton | 1 - 1 | 95 | -1 |
| 19/12/2020 | Southampton vs Man City | 0 - 1 | 41 | 0 |
| 29/12/2020 | Southampton vs West Ham | 0 - 0 | 94 | 0 |
| 04/01/2021 | Southampton vs Liverpool | 1 - 0 | 77 | 4 |
| 20/01/2021 | Leeds United vs Southampton | - | - | - |
| 26/01/2021 | Southampton vs Arsenal | - | - | - |
| 30/01/2021 | Southampton vs Aston Villa | - | - | - |
| 02/02/2021 | Man United vs Southampton | - | - | - |
| 06/02/2021 | Newcastle vs Southampton | - | - | - |
| 13/02/2021 | Southampton vs Wolverhampton Wanderers | - | - | - |
| 20/02/2021 | Southampton vs Chelsea | - | - | - |
| 27/02/2021 | Everton vs Southampton | - | - | - |
| 06/03/2021 | Sheffield United vs Southampton | - | - | - |
| 13/03/2021 | Southampton vs Brighton | - | - | - |
| 20/03/2021 | Tottenham vs Southampton | - | - | - |
| 03/04/2021 | Southampton vs Burnley | - | - | - |
| 10/04/2021 | West Brom vs Southampton | - | - | - |
| 17/04/2021 | Southampton vs Crystal Palace | - | - | - |
| 24/04/2021 | Man City vs Southampton | - | - | - |
| 01/05/2021 | Southampton vs Leicester | - | - | - |
| 08/05/2021 | Liverpool vs Southampton | - | - | - |
| 12/05/2021 | Southampton vs Fulham | - | - | - |
| 15/05/2021 | Southampton vs Leeds United | - | - | - |
| 23/05/2021 | West Ham vs Southampton | - | - | - |
