| 27/09/2020 | Cádiz vs Sevilla | 1 - 3 | 97 | 0 |
| 01/10/2020 | Sevilla vs Levante | 1 - 0 | 95 | 4 |
| 04/10/2020 | Barcelona vs Sevilla | 1 - 1 | 95 | 0 |
| 17/10/2020 | Granada vs Sevilla | 1 - 0 | 95 | 0 |
| 24/10/2020 | Sevilla vs Eibar | 0 - 1 | 95 | 0 |
| 31/10/2020 | Athletic Bilbao vs Sevilla | 2 - 1 | 94 | -2 |
| 07/11/2020 | Sevilla vs Osasuna | 1 - 0 | 94 | 5 |
| 21/11/2020 | Sevilla vs Celta Vigo | 4 - 2 | 94 | -1 |
| 28/11/2020 | Huesca vs Sevilla | 0 - 1 | 94 | 5 |
| 05/12/2020 | Sevilla vs Real Madrid | 0 - 1 | 80 | 0 |
| 12/12/2020 | Getafe vs Sevilla | 0 - 1 | 95 | 4 |
| 19/12/2020 | Sevilla vs Real Valladolid | 1 - 1 | 96 | 0 |
| 22/12/2020 | Valencia vs Sevilla | 0 - 1 | 93 | 5 |
| 29/12/2020 | Sevilla vs Villarreal | 2 - 0 | 94 | 5 |
| 02/01/2021 | Real Betis vs Sevilla | 1 - 1 | 95 | 0 |
| 09/01/2021 | Sevilla vs Real Sociedad | 3 - 2 | 93 | -1 |
| 12/01/2021 | Atletico Madrid vs Sevilla | 2 - 0 | 94 | -1 |
| 30/01/2021 | Eibar vs Sevilla | 0 - 2 | 13 | 5 |
| 06/02/2021 | Sevilla vs Getafe | 3 - 0 | 100 | 5 |
| 13/02/2021 | Sevilla vs Huesca | 1 - 0 | 94 | 5 |
| 22/02/2021 | Osasuna vs Sevilla | 0 - 2 | 93 | 9 |
| 27/02/2021 | Sevilla vs Barcelona | 0 - 2 | 45 | -2 |
| 14/03/2021 | Sevilla vs Real Betis | 1 - 0 | 94 | 4 |
| 20/03/2021 | Real Valladolid vs Sevilla | 1 - 1 | 95 | 0 |
| 04/04/2021 | Sevilla vs Atletico Madrid | 1 - 0 | 95 | 4 |
| 12/04/2021 | Celta Vigo vs Sevilla | 3 - 4 | 94 | -3 |
| 18/04/2021 | Real Sociedad vs Sevilla | 1 - 2 | 94 | -1 |
| 21/04/2021 | Levante vs Sevilla | 0 - 1 | 94 | 5 |
| 25/04/2021 | Sevilla vs Granada | 2 - 1 | 101 | 0 |
| 03/05/2021 | Sevilla vs Athletic Bilbao | 0 - 1 | 85 | -1 |
| 09/05/2021 | Real Madrid vs Sevilla | 2 - 2 | 97 | -1 |
| 12/05/2021 | Sevilla vs Valencia | 1 - 0 | 96 | 5 |
| 16/05/2021 | Villarreal vs Sevilla | 4 - 0 | 94 | -5 |
